Mechanical stress determines the configuration of TGFβ activation in articular cartilage

G Zhen, Q Guo, Y Li, C Wu, S Zhu, R Wang… - Nature …, 2021 - nature.com
… live cell biomechanical testing in chondrocytes isolated from … system of chondrocytes,
which coordinates cytoskeleton … on a single integrin–ligand bond exerted by the chondrocyte, …

… : mechanisms and opportunities to control multiple molecular aspects of cell phenotype as a design cornerstone of cell-instructive biomaterials for articular cartilage …

M Selig, JC Lauer, ML Hart, B Rolauffs - International journal of molecular …, 2020 - mdpi.com
One of the key biomechanical determinants is the stiffness of … cytoskeleton and studies have
shown that biomechanical … with TGF-β1 (and IGF-I) and subsequent increases in F-actin [179]…

Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression

Q Liu, X Hu, X Zhang, X Duan, P Yang, F Zhao… - Scientific Reports, 2016 - nature.com
… to detect biomechanics of the intact and damage cartilage, … the AFM tip/bead over a single
chondrocyte and the 3d-height … by regulating the cytoskeleton arrangement and expression. …

A novel construct with biomechanical flexibility for articular cartilage regeneration

B Cheng, T Tu, X Shi, Y Liu, Y Zhao, Y Zhao… - Stem Cell Research & …, 2019 - Springer
cartilage transplant with biomechanical flexibility that may show a superior capacity for cartilage
… The temporomandibular joint (TMJ) is one of the most sophisticated and frequently used …

Articular cartilage tissue engineering: the role of signaling molecules

H Kwon, NK Paschos, JC Hu, K Athanasiou - Cellular and molecular life …, 2016 - Springer
… Changes in biomechanical characteristics of articular cartilage and … , one of the major
design criteria in cartilage tissue engineering is the creation of neocartilage with biomechanical

Downregulation of HAS‑2 regulates the chondrocyte cytoskeleton and induces cartilage degeneration by activating the RhoA/ROCK signaling pathway

J Yang, L Wang, Z Zhang… - … Journal of Molecular …, 2023 - spandidos-publications.com
chondrocyte cytoskeleton protein expression, leading to changes in the signal transduction
and biomechanical properties of chondrocytes, … cytoskeleton protein in a single chondrocyte

The tendon unit: biochemical, biomechanical, hormonal influences

N Maffulli, F Cuozzo, F Migliorini, F Oliva - Journal of Orthopaedic Surgery …, 2023 - Springer
… The other 10% is composed of chondrocytes close to the insertion of the tendon to bone, …
cytoskeleton, integrins, g proteins and stretching-activated ion channel [26]. The cytoskeleton is …

[HTML][HTML] Synthesis and characterization of polyphosphazene microspheres incorporating demineralized bone matrix scaffolds controlled release of growth factor for …

B Ren, X Hu, J Cheng, Z Huang, P Wei, W Shi… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… PAGP70 microsphere and IGF-I from PAGP30 microsphere … To evaluate the effect of GFs
on the chondrogenic phenotype… rhodamine phalloidin (160 nM; Cytoskeleton Inc. USA) for 1 h …

Harnessing growth factor interactions to optimize articular cartilage repair

SB Trippel - … of Cartilage and Osteoarthritis: A Tribute to Alan …, 2023 - Springer
… Leipzig ND, Eleswarapu SV, Athanasiou KA (2006) The effects of TGF-beta1 and IGF-I
on the biomechanics and cytoskeleton of single chondrocytes. Osteoarthritis and …

Cartilage tissue engineering

EE Coates, JP Fisher - Molecular, Cellular, and Tissue …, 2018 - api.taylorfrancis.com
… Similarly, bovine chondrocytes in devitalized cartilage constructs showed increased …
effects of TGF-beta1 and IGF-I on the biomechanics and cytoskeleton of single chondrocytes